Type I interferon pathway in adult and juvenile dermatomyositis
نویسندگان
چکیده
Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. The most prominent and consistent feature has been a characteristic whole blood gene signature indicating upregulation of the type I interferon pathway. Upregulation of the type I interferon protein signature has added additional markers of disease activity and insight into the pathogenesis of the disease.
منابع مشابه
Interferon-inducible gene expression in dermatomyositis muscle
Gene expression profi ling of peripheral blood or aff ected tissues in patients with autoimmune diseases has revealed important insights into the molecular pathways underlying autoimmunity [1]. Several groups have used gene expression profi ling in an attempt to uncover clues to the pathogenesis of dermatomyositis (DM) (Table 1). Th e most prominent and consistent fi nding of these studies has ...
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